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欧盟评估转基因酿酒酵母菌株LALL-GO生产的葡糖氧化酶的安全性

放大字体  缩小字体 发布日期:2023-10-10  来源:食品伙伴网  作者:泽夕  浏览次数:92
核心提示:2023年10月6日,欧盟食品安全局就一种葡糖氧化酶(glucose oxidase)的安全性评价发布意见。
   食品伙伴网讯  2023年10月6日,欧盟食品安全局就一种葡糖氧化酶(glucose oxidase)的安全性评价发布意见。
 
  据了解,这种食品酶是由转基因酿酒酵母菌株LALL-GO生产的,旨在用于烘焙过程。
 
  经过评估,专家小组认为,在预期的使用条件下,不能排除饮食暴露引起过敏反应的风险。除了潜在的过敏反应之外,评估小组得出结论,这种食品酶在预期使用条件下不会引起安全问题。部分原文报道如下:
 
  The food enzyme glucose oxidase (β-d-glucose:oxygen 1-oxidoreductase; EC 1.1.3.4) is produced with the genetically modified Saccharomyces cerevisiae strain LALL-GO by Lallemand Inc. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism, but not from recombinant DNA. It is intended to be used in baking processes. Dietary exposure was estimated to be up to 0.233 mg total organic solids/kg body weight per day in European populations. Since the production strain meets the requirements for the Qualified Presumption of Safety approach and no issues of concern arising from the production process of the food enzyme were identified, the Panel considered that no toxicological studies were necessary. A search for the similarity of the amino acid sequence of the food enzyme to known allergens was made and two matches were found. The Panel considered that, under the intended conditions of use, the risk of allergic reactions upon dietary exposure to this food enzyme cannot be excluded. The glucose oxidase under assessment shows sequence homology with an allergen from almond, which is listed in the Annex II of the Regulation (EU) No 1169/2011. Other than potential allergic reactions, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.
 
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