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欧盟评估转基因枯草芽孢杆菌菌株MAMDSM生产的葡聚糖1,4-α-麦芽水解酶的安全性

放大字体  缩小字体 发布日期:2023-11-24  来源:食品伙伴网  作者:泽夕  浏览次数:42
核心提示:2023年11月23日,欧盟食品安全局就一种葡聚糖1,4-α-麦芽水解酶(glucan 1,4-α-maltohydrolas)的安全性评价发布意见。
   食品伙伴网讯  2023年11月23日,欧盟食品安全局就一种葡聚糖1,4-α-麦芽水解酶(glucan 1,4-α-maltohydrolas)的安全性评价发布意见。
 
  据了解,这种食品酶是由转基因枯草芽孢杆菌菌株MAMDSM生产的,旨在用于谷物和其他谷物的加工,以生产烘焙和酿造产品。
 
  经过评估,专家小组认为,在预期的使用条件下,不能排除饮食暴露引起过敏和诱发反应的风险,但这种情况发生的可能性很低。根据所提供的数据,评估小组得出结论,这种食品酶在预期使用条件下不会引起安全问题。部分原文报道如下:
 
  The food enzyme glucan 1,4-α-maltohydrolase (4-α-d-glucan α-maltohydrolase; EC 3.2.1.133) is produced with the genetically modified Bacillus subtilis strain MAMDSM by DSM Food Specialties. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and its DNA. It is intended to be used in the processing of cereals and other grains for the production of baked and brewed products. Dietary exposure to the food enzyme–total organic solids (TOS) was estimated to be up to 0.204 mg TOS/kg body weight (bw) per day in European populations. The production strain meets the requirements for the QPS approach. As no concerns arising from the manufacturing process have been identified, the Panel considered that toxicological tests were not needed for the assessment of this food enzyme. A search for the similarity of the amino acid sequence of the food enzyme to known allergens was made and four matches were found. The Panel considered that the risk of allergic reactions by dietary exposure cannot be excluded, but the likelihood is low. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use.
 
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