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欧盟评估扩展使用转基因里氏木霉菌株 AR-852生产的纤维素酶的安全性

放大字体  缩小字体 发布日期:2026-03-27  来源:食品伙伴网  作者:泽夕  浏览次数:27
核心提示:2026年3月26日,欧盟食品安全局就一种食品酶纤维素酶(cellulase)的安全性评价发布意见。
   食品伙伴网讯  2026年3月26日,欧盟食品安全局就一种食品酶纤维素酶(cellulase)的安全性评价发布意见。
 
  据了解,这种食品酶是由转基因里氏木霉菌株AR-852生产的,旨在用于六种食品生产过程。
 
  经过评估,专家小组得出结论,这种食品酶在预期使用条件下不会引起安全问题。部分原文报道如下:
 
  The food enzyme cellulase (4-(1,3;1,4)-β-d-glucan 4-glucanohydrolase; EC 3.2.1.4) is produced with the genetically modified Trichoderma reesei strain AR-852 by AB Enzymes GmbH. The safety of this food enzyme was evaluated previously, and it did not give rise to safety concerns when used in five food manufacturing processes. Subsequently, the applicant has requested to extend its use to include one additional process and to revise the use levels. In this assessment, EFSA updated the safety evaluation of this food enzyme when used in a total of six food manufacturing processes. As the food enzyme–total organic solids (TOS) are removed in one process, the dietary exposure to the food enzyme–TOS was estimated for the remaining five food manufacturing processes. It was estimated to be up to 0.494 mg TOS/kg body weight (bw) per day in European populations. When combined with the no observed adverse effect level (NOAEL) previously reported (1000 mg TOS/kg bw per day, the highest dose tested), the Panel derived a margin of exposure of at least 2024. based on the revised margin of exposure and the previous evaluation, the Panel concluded that this food enzyme does not give rise to safety concerns under the revised intended conditions of use.
 
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